The Fragility of Statistically Significant Findings from Randomized Controlled Trials in Hip and Knee Arthroplasty
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By: Seper Ekhtiari, Aaron Gazendam, Nicholas Nucci, Colin Kruse, Mohit Bhandari
Posted on: December 12, 2020
The Fragility of Statistically Significant Findings from Randomized Controlled Trials in Hip and Knee Arthroplasty
The fragility index (FI) is a method for evaluating the robustness of statistically significant findings from randomized controlled trials (RCTs) beyond the P value in trials with dichotomous outcomes. The FI is defined as the number of patients in one arm of a trial that would have to have a different outcome to change the results of the trial from statistically significant to nonsignificant. This review assessed the FI in arthroplasty RCTs.
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